The Genome of a Very Virulent Marek's Disease Virus

The genome of a very virulent Marek's disease virus.

Here we present the first complete genomic sequence, with analysis, of a very virulent strain of Marek's disease virus serotype 1 (MDV1), Md5. The genome is 177,874 bp and is predicted to encode 103 proteins. MDV1 is colinear with the prototypic alphaherpesvirus herpes simplex virus type 1 (HSV-1) within the unique long (UL) region, and it is most similar at the amino acid level to MDV2, herpes...

Sequence analysis of the VP1 gene in three very virulent Iranian infectious bursal disease virus strains

Infectious bursal disease (IBD) is a highly contagious disease of chickens caused by the infectious bursal disease virus (IBDV). This study was conducted to characterize three IBDV strains from Iran. A reverse transcriptase-polymerase chain reaction (RT-PCR) procedure was used to amplify a 715-bp fragment of the VP1 gene from IBDV strains. Amplified VP1 fragments of the three Iranian IBDV strai...

Very Virulent Infectious Bursal Disease Virus

The primary feature of vvIBDV is the ability to induce high mortality. Mortality ranges from 5% – 25% in broilers and 30% – 70% in layers. Surviving birds are severely affected with a high condemnation rate. vvIBDV induces clinical signs similar to Gumboro disease, which is induced by classical virulent strains of IBDV, except that the disease is more pronounced and acute in individual birds an...

Characterization of a Highly Virulent Infectious Bursal Disease Virus

Genome Sequence of a Novel Reassortant and Very Virulent Strain of Infectious Bursal Disease Virus

Here, we report the complete coding genome sequence of a novel reassortant and very virulent infectious bursal disease virus (IBDV), designated JBN2011. Characterization of the JBN2011 genome suggests that it is a rare recombinant virus having a very virulent IBDV segment A and a Bursine-2-like attenuated IBDV segment B.